TY - JOUR ID - 15487 TI - Hypersensitivity and cross-reactivity to cisplatin and carboplatin. JO - Journal of Emergency Practice and Trauma JA - JEPT LA - en SN - AU - Faridaalaee, Gholamreza AU - Rahmani, Seyed Hesam AU - Mahboubi, Amin AD - Emergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, Iran AD - Emergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran Y1 - 2016 PY - 2016 VL - 2 IS - 2 SP - 58 EP - 61 KW - Cisplatin KW - Carboplatin KW - Cross-reactivity KW - cancer KW - Anaphylaxis DO - 10.15171/jept.2016.09 N2 - Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergency department (ED) with shortness of breath, tachypnea, restless, agitation, and lethargy. On arrival, the patient was hemodynamically unstable; we initiated treatment immediately with hydration, oxygen therapy with mask, hydrocortisone, midazolam, and adrenalin. After 1 hour, BP and O2 sat improved to 100/70 mm Hg and 92% respectively, but there was not any significant improvement in tachycardia as well as tachypnea and she was still lethargic and agitated. Her symptoms improved gradually after 18 hours of admission. She was discharged after 36 hours. HSRs to cisplatin and carboplatin can be potentially life-threatening. The symptoms can range from a mild rash to severe anaphylaxis. Doctors should be aware of these reactions, determine appropriate treatment, and know the cross-reactivity among these drugs.   UR - http://www.jept.ir/article_15487.html L1 - http://www.jept.ir/article_15487_cc7e8503f00163755fb27175dcbd54dd.pdf ER -