Anesthesiology
Behzad Nazemroaya; Azim Honarmand; Golshan Mazaheri Tehrani
Volume 9, Issue 2 , July 2023, , Pages 97-103
Abstract
Objective: Etomidate is mentioned as one of the rapid intravenous anesthetic drugs whose unique characteristics include hemodynamic stability, negligible respiratory depression, and brain protection. The most common complication of etomidate is intravenous pain during injection. The purpose of this study ...
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Objective: Etomidate is mentioned as one of the rapid intravenous anesthetic drugs whose unique characteristics include hemodynamic stability, negligible respiratory depression, and brain protection. The most common complication of etomidate is intravenous pain during injection. The purpose of this study was to compare the effectiveness of the Valsalva maneuver and fentanyl in reducing the pain caused by etomidate injection for anesthesia induction.Methods: This clinical trial was performed on 96 patients at Alzahra hospital, affiliated with the Isfahan University of Medical Sciences, from January to June 2021. Patients were divided into two groups of 48 people: the Valsalva maneuver group (group 1) and the fentanyl group (group 2). Blood pressure, heart rate (HR), oxygen saturation, and pain of etomidate injection using the withdrawal response score were graded on a four-point scale (no pain = zero, mild pain = 1, average pain = 2, and severe pain = 3). The collected information was entered into SPSS software version 24. Then, the pain score in the two groups was compared using the chi-square test. The significance level in the present study was P < 0.05.Results: The mean HR (P = 0.07), mean arterial pressure (MAP) (P = 0.33), systolic pressure (P = 0.90), diastolic pressure (P = 0.67), and oxygen saturation level (P = 0.27) at different times between the two groups showed no significant difference (P > 0.05). However, during the etomidate injection, the HR increased and after the injection, the HR decreased in both groups (P = 0.042). The two groups had no significant difference regarding pain frequency.Conclusion: There was no difference in the effect of the Valsalva maneuver and fentanyl on reducing the pain caused by etomidate injection.
Trauma
Zahra Rahim; Mehrdad MasoudifarI; Behzad Nazemroaya; Mehrdad Norouzi; Amirali Mousavi I
Volume 9, Issue 1 , January 2023, , Pages 25-31
Abstract
Objective: In general, spinal fusion surgery causes heavy bleeding. The purpose of thisstudy was to evaluate the use of two different doses of magnesium sulfate to control thebleeding in lumbar fusion surgery.Methods: This study was carried out as a randomized double-blinded clinical trial in 2020in ...
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Objective: In general, spinal fusion surgery causes heavy bleeding. The purpose of thisstudy was to evaluate the use of two different doses of magnesium sulfate to control thebleeding in lumbar fusion surgery.Methods: This study was carried out as a randomized double-blinded clinical trial in 2020in Al-Zahra hospital in Isfahan. The participants were 60 patients selected using inclusionand exclusion criteria and were randomly allocated into three groups. In the first group,50 mg/kg and in the second group, 40 mg/kg magnesium sulfate was infused. The thirdgroup received normal saline. From the beginning of anesthesia, heart rate, diastolic andsystolic blood pressure, respiratory rate and blood oxygen saturation percentage weremonitored and logged every 30 minutes during the operation and recovery. The volumeof bleeding during the operation was calculated by counting the number of gauzes usedand the amount of suctioned blood during the operation. Other required informationsuch as the duration of operation, duration of anesthesia, time of intubation and the timeperiod of hospitalization and recovery were determined and recorded in all patients. Weused independent t-test and repeated measure ANOVA tests to compare data betweendifferent time lines and also different groups. P value<0.05 was considered as significancethreshold. The collected data were analyzed by using SPSS software version 23.Results: The group receiving 50 mg/kg magnesium sulfate had a significantly lower systolicblood pressure compared to other groups within 15, 30 and 45 minutes after the injections(P=0.04 for all). The pulse rate was significantly lower in the 50 mg/kg magnesium sulfategroup compared to other groups within 15, 30 and 45 minutes after the injections (P<0.05for all). Patients that received 50 mg/kg magnesium sulfate had a lower duration of surgery(P=0.007), lower duration of anesthesia (P=0.007), lower bleeding volume (P<0.001),lower fluid intake (P=0.01) and also lower transfused blood (P=0.01). The surgeons alsohad a significantly higher satisfaction with these patients (P=0.001).Conclusion: Injection of 50 mg/kg magnesium sulfate had a correlation with reducedblood pressure as well as bleeding volume compared to 40 mg/kg magnesium sulfate.