Document Type : Original Article
Authors
1
Shahid Rajaii hospital Padegan Blv
2
Medical Doctor, Qazvin University of Medical Sciences, Qazvin, Iran
3
Associate professor of Medical Informatics, Department of Community Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4
Social Determinants of Health Research Center, Research Institute for prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
5
Associate professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract
Background: Trauma-related injuries are a leading cause of hospitalization and mortality worldwide. In response to trauma, pathological and anti-inflammatory processes occur, characterized by an increase in neutrophils and a decrease in lymphocytes. This study aimed to assess the prognostic value of the Neutrophil-to-Lymphocyte Ratio (NLR) in predicting outcomes in multiple trauma patients, focusing on hospital stay length and mortality.
Methods: The study included 474 adult trauma patients (ages 14 to 80) who presented to the Trauma Center of Qazvin Province in the first half of 2024. The Injury Severity Score (ISS) was used to classify patients, and data from Complete Blood Count (CBC) and Differential Count (Diff) tests were collected. Statistical analysis was conducted using the Kolmogorov-Smirnov test for data normality, the Chi-square test for qualitative variables, and Pearson’s correlation coefficient for quantitative variables. Data analysis was done using SPSS version 16.
Results: The 67.7% of patients were male, and the mortality rate was 9.72%. The average NLR was 3.9, with a cutoff point identified by maximizing the Youden Index. Cox regression analysis showed that NLR > 3.9 was significantly associated with prolonged hospital stays and ICU admissions (P < 0.001, P < 0.004). Additionally, 69% of the patients who died had an NLR greater than 3.9 (P < 0.001).
Conclusion: In conclusion, NLR > 3.9 serves as a reliable prognostic marker for adverse outcomes, including prolonged hospitalization and increased mortality. The NLR is a simple, cost-effective tool that could be implemented in clinical settings to predict patient prognosis and guide more effective interventions. Further research is needed to confirm these findings and investigate the mechanisms by which NLR influences trauma outcomes.
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