Cardiology
Afshin Amini; Maryam Ahmadi Chegeni; Zahra Soltanzadeh Khasraghi; Mohammad Parsa Mahjoob; Sina Shool; Amir Ghabousian; Rozita Khatamian Oskooi; Saeed Safari
Volume 8, Issue 2 , July 2022, , Pages 110-114
Abstract
Objective: The significance of diagnosing the root reason for syncope and taking therequired preventive or treatment measures cannot be overlooked when it comes tooutcome prediction. This study endeavors to examine the role of proBNP in differentiatingcardiogenic and non-cardiogenic syncope in patients ...
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Objective: The significance of diagnosing the root reason for syncope and taking therequired preventive or treatment measures cannot be overlooked when it comes tooutcome prediction. This study endeavors to examine the role of proBNP in differentiatingcardiogenic and non-cardiogenic syncope in patients presenting to the emergencydepartment (ED).Methods: We prospectively performed a cross-sectional study on patients presentingwith acute syncope. All the patients for this investigation were followed up until thedefinite cause of their syncope (cardiac or non-cardiac) was diagnosed and the screeningperformance characteristics of proBNP in differentiation of cardiogenic and noncardiogenic syncope were evaluated.Results: Three hundred patients with syncope were studied (64.7% male). In the end,the cause of syncope was determined to be cardiogenic in 133 cases (44.3%). The areaunder the ROC curve of proBNP in the differentiation of cardiogenic syncope from noncardiogenic was estimated to be 78.9 (95% CI: 73.5 – 84.3). The optimal cut-off point forproBNP in this regard was 143.5 pg/mL point. Sensitivity, specificity, positive and negativepredictive values, and positive and negative likelihood ratios of proBNP in the mentionedcut-off point were 75.39% (95% CI: 67.61–82.73), 75.44% (95% CI: 68.07–81.62), 71.12%(95% CI: 62.82–78.26), 79.74% (95% CI: 72.46–85.54), 2.46 (95% CI: 1.86–3.25), and 0.25(95% CI: 0.18–0.34), respectively.Conclusion: The accuracy of proBNP in differentiation of cardiogenic and non-cardiogenicsyncope is fair. ProBNP concentration equals to or higher than 143.5 pg/mL can differentiatecardiogenic syncope from non-cardiogenic with 75% sensitivity and 76% specificity. Itseems that its use for this purpose should be considered with caution and along with othertools
Infectious disease
Saeed Safari; Mahmoud Yousefifard
Volume 7, Issue 1 , January 2021, , Pages 4-6
Abstract
The coronavirus disease 2019 (COVID-19) was first emerged from Wuhan, China, in late 2019, and has since been spreading progressively all around the world. Its prevalence is climbing increasingly and almost all countries worldwide are confronting this pandemic. As of April 11, 2020, reports obtained ...
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The coronavirus disease 2019 (COVID-19) was first emerged from Wuhan, China, in late 2019, and has since been spreading progressively all around the world. Its prevalence is climbing increasingly and almost all countries worldwide are confronting this pandemic. As of April 11, 2020, reports obtained about the management of COVID-19 patients indicate that the mortality rate of the disease is around 5% with consideration of the active cases and 21% of the closed cases
OB/GYN
Aboutaleb Beigi; Alireza Mazinanian; Mansour Ashrafinia; Alireza Baratloo; Saeed Safari
Volume 1, Issue 1 , January 2015, , Pages 19-21
Abstract
Objective: There are major differences in neonatal and obstetrics outcomes of labour among different ethnicities. The present study compared the neonatal and obstetrics outcomes of labour between the Iranian and Afghan ethnicities. Methods: Neonatal and obstetrics problems were evaluated in Iranian ...
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Objective: There are major differences in neonatal and obstetrics outcomes of labour among different ethnicities. The present study compared the neonatal and obstetrics outcomes of labour between the Iranian and Afghan ethnicities. Methods: Neonatal and obstetrics problems were evaluated in Iranian and Afghan pregnant women, who had referred to Arash Educational/Treatment Center for labour during a year. Results: 3020 (93.7%) Iranian and 202 (63%) Afghan women were evaluated. There were no significant differences between the two ethnicities in relation to a need for Neonatal Intensive Care Unit (NICU), the rate of live births, infant birth weight, congenital anomalies and premature births (P>0.05). The rate of Caesarian section was higher in Iranian women (P=0.001). Conclusion: It seems that the differences in neonatal problems and outcomes of labour obstetrics between Iranians and Afghans can be attributed to different cultural, economic, and social conditions in comparison to different ethnicities.
Cardiology
Alireza Baratloo; Pauline Haroutunian; Alaleh Rouhipour; Saeed Safari; Farhad Rahmati
Volume 1, Issue 1 , January 2015, , Pages 35-38
Abstract
Background: Potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. High serum potassium levels are thought to impair ...
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Background: Potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. High serum potassium levels are thought to impair pulse conduction in Purkinje fibers and ventricles more than that in the Atrioventricular (AV) node. Therefore, although complete AV block can occur, it is a rare initial presentation.
Case Report: We describe a 62-year-old man with a history of diabetes mellitus, ischemic heart disease and previous Coronary Artery Bypass Graft (CABG), who came to our emergency department due to generalized weakness starting 2 days before admission. The patient also had decreased force in lower limbs, exacerbating from the morning, and was finally diagnosed as a hyperkalemia-induced Complete Heart Block (CHB). It should also be noted that the patient responded dramatically to the administration of 10 mL of 10% calcium gluconate along with external pacing until potassium level correction became effective. Conclusion: In spite of the fact that Hyperkalemia can be associated with frequent Electrocardiogram (ECG) abnormality, advanced heart blocks (second- and third-degree AV blocks) are usually found only in patients with pre-existing heart failure, conduction abnormalities, or other cardiac diseases. Institution of effective treatment rapidly and forgiveness of traditional non-effective, time consumptive and sometimes risking full-adjustment modalities, such as sodium bicarbonate infusion or exchange resins that prevent their use in the emergent phase, can help minimize patient morbidity and mortality.